Issue 23, 2003
From the journal:

Chemical Communications

The C-terminal ester of membrane anchored peptide ion channels affects anion transport

Natasha Djedovic,a   Riccardo Ferdani,a   Egan Harder,b   Jolanta Pajewska,a   Robert Pajewski,a   Paul H. Schlesingerb  and  George W. Gokel*a  

* Corresponding authors

a Departments of Chemistry and Molecular Biology & Pharmacology and Cell Biology and Physiology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8103, St. Louis, MO 63110, USA

b Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8103, St. Louis, MO 63110, USA

Abstract

Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.

Graphical abstract: The C-terminal ester of membrane anchored peptide ion channels affects anion transport

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Article information

DOI
https://doi.org/10.1039/B312209N
Article type
Communication
Submitted
27 Sep 2003
Accepted
02 Oct 2003
First published
23 Oct 2003

Chem. Commun., 2003, 2862-2863

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The C-terminal ester of membrane anchored peptide ion channels affects anion transport

N. Djedovic, R. Ferdani, E. Harder, J. Pajewska, R. Pajewski, P. H. Schlesinger and G. W. Gokel, Chem. Commun., 2003, 2862 DOI: 10.1039/B312209N

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