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Issue 23, 2003
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Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids

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Abstract

The oxidation of polyunsaturated fatty acids such as arachidonic and linoleic acid initiates a plethora of cell signaling pathways in animals and plants. The chemistry of the enzymatic oxidation has been investigated for several enzymes, most notably prostaglandin synthase and the lipoxygenases, revealing many surprises and impressive examples of enzymatic control of hydrogen atom abstraction and subsequent oxygenation.

Graphical abstract: Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids

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Publication details

The article was first published on 03 Nov 2003


Article type: Focus
DOI: 10.1039/B311008G
Chem. Commun., 2003, 2843-2846

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    Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids

    C. M. McGinley and W. A. van der Donk, Chem. Commun., 2003, 2843
    DOI: 10.1039/B311008G

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