Issue 23, 2003
From the journal:

Chemical Communications

Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids

Chris M. McGinleya  and  Wilfred A. van der Donk*a  

* Corresponding authors

a Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, Illinois, USA
E-mail: vddonk@uiuc.edu
Fax: + 1 217 244 8068
Tel: +1 217 244 5360

Abstract

The oxidation of polyunsaturated fatty acids such as arachidonic and linoleic acid initiates a plethora of cell signaling pathways in animals and plants. The chemistry of the enzymatic oxidation has been investigated for several enzymes, most notably prostaglandin synthase and the lipoxygenases, revealing many surprises and impressive examples of enzymatic control of hydrogen atom abstraction and subsequent oxygenation.

Graphical abstract: Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids

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Article information

DOI
https://doi.org/10.1039/B311008G
Article type
Focus
First published
03 Nov 2003

Chem. Commun., 2003, 2843-2846

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Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids

C. M. McGinley and W. A. van der Donk, Chem. Commun., 2003, 2843 DOI: 10.1039/B311008G

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