Issue 22, 2003
From the journal:

Chemical Communications

Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase

Carlos Olano,a   Barrie Wilkinson,b   Steven J. Moss,b   Alfredo F. Braña,a   Carmen Méndez,a   Peter F. Leadlaybc  and  José A. Salas*a  

* Corresponding authors

a Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain
E-mail: jasalas@correo.uniovi.es
Fax: +34-985-103652
Tel: +34-985-103652

b Biotica Technology Ltd, 181A Huntingdon Road, Cambridge, UK

c Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK

Abstract

Functional evidence for programmed loss of co-linearity on the borrelidin modular polyketide synthase (PKS) is presented.

Graphical abstract: Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase

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Article information

DOI
https://doi.org/10.1039/B310648A
Article type
Communication
Submitted
02 Sep 2003
Accepted
29 Sep 2003
First published
15 Oct 2003

Chem. Commun., 2003, 2780-2782

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Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase

C. Olano, B. Wilkinson, S. J. Moss, A. F. Braña, C. Méndez, P. F. Leadlay and J. A. Salas, Chem. Commun., 2003, 2780 DOI: 10.1039/B310648A

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