Issue 23, 2003
From the journal:

Chemical Communications

Cell-permeable small molecule probes for site-specific labeling of proteins†

Dawn S. Y. Yeo,a   Rajavel Srinivasan,b   Mahesh Uttamchandani,a   Grace Y. J. Chen,ab   Qing Zhub  and  Shao Q. Yao*ab  

* Corresponding authors

a Department of Biological Sciences, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore
E-mail: chmyaosq@nus.edu.sg
Fax: 65 6779 1691
Tel: 65 6874 1683

b Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore
E-mail: chmyaosq@nus.edu.sg
Fax: 65 6779 1691
Tel: 65 6874 1683

Abstract

We have successfully synthesized a number of small molecule probes designed for site-specific labeling of N-terminal cysteine-containing proteins expressed in live cells. Their utility for site-specific, covalent modifications of proteins was successfully demonstrated with purified proteins in vitro, and with live bacterial cells in vivo.

Graphical abstract: Cell-permeable small molecule probes for site-specific labeling of proteins

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Article information

DOI
https://doi.org/10.1039/B309196A
Article type
Communication
Submitted
05 Aug 2003
Accepted
14 Oct 2003
First published
29 Oct 2003

Chem. Commun., 2003, 2870-2871

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Cell-permeable small molecule probes for site-specific labeling of proteins

D. S. Y. Yeo, R. Srinivasan, M. Uttamchandani, G. Y. J. Chen, Q. Zhu and S. Q. Yao, Chem. Commun., 2003, 2870 DOI: 10.1039/B309196A

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