Issue 20, 2003
From the journal:

Chemical Communications

Catalytic enantioselective transaminiation of α-keto esters: an organic approach to enzymatic reactions

Kristian Rahbek Knudsen,a   Stephan Bachmanna  and  Karl Anker Jørgensen*a  

* Corresponding authors

a Danish National Research Foundation: Centre for Catalysis, Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark
E-mail: kaj@chem.au.dk
Fax: +45 8619 6199
Tel: +45 8942 3910

Abstract

The half-transamination reaction of α-keto esters with pyridoxamine or 4-picolylamine was found to be catalysed by different metal catalysts in organic solvents giving moderate yields and enantioselectivities of up to 37% ee for methyl-3-indole pyruvate.

Graphical abstract: Catalytic enantioselective transaminiation of α-keto esters: an organic approach to enzymatic reactions

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Article information

DOI
https://doi.org/10.1039/B308395K
Article type
Communication
Submitted
22 Jul 2003
Accepted
29 Aug 2003
First published
19 Sep 2003

Chem. Commun., 2003, 2602-2603

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Catalytic enantioselective transaminiation of α-keto esters: an organic approach to enzymatic reactions

K. R. Knudsen, S. Bachmann and K. A. Jørgensen, Chem. Commun., 2003, 2602 DOI: 10.1039/B308395K

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