Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans

Hui Hong; Paul J. Gates; James Staunton; Tim Stinear; Stewart T. Cole; Peter F. Leadlay; Jonathan B. Spencer

doi:10.1039/B308163J

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Identification using LC-MSⁿ of co-metabolites in the biosynthesis of the polyketidetoxinmycolactone by a clinical isolate of Mycobacterium ulcerans†

Hui Hong,^a Paul J. Gates,^a James Staunton,^a Tim Stinear,^b Stewart T. Cole,^b Peter F. Leadlay^ab and Jonathan B. Spencer*^a

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* Corresponding authors

^a Departments of Chemistry and Biochemistry, University of Cambridge, Cambridge, UK
E-mail: jbs20@cam.ac.uk
Fax: 01223 336362
Tel: 01223 331696

^b Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, Paris 75015, France

Abstract

LC-MSⁿ analysis of mycolactone toxin from extracts of Mycobacterium ulcerans has shown that minor co-metabolites, including two previously unreported, differ structurally from mycolactone only in a small portion of the polyketide side-chain.

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Article information

DOI: https://doi.org/10.1039/B308163J
Article type: Communication
Submitted: 17 Jul 2003
Accepted: 05 Aug 2003
First published: 20 Oct 2003

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Chem. Commun., 2003, 2822-2823

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Identification using LC-MSⁿ of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans

H. Hong, P. J. Gates, J. Staunton, T. Stinear, S. T. Cole, P. F. Leadlay and J. B. Spencer, Chem. Commun., 2003, 2822 DOI: 10.1039/B308163J

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Chemical Communications