Issue 17, 2003
From the journal:

Chemical Communications

Functionalized LNA (locked nucleic acid): high-affinity hybridization of oligonucleotides containing N-acylated and N-alkylated 2′-amino-LNA monomers†

Mads D. Sørensen,a   Michael Petersenb  and  Jesper Wengel*b  

* Corresponding authors

a Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark

b Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark

Abstract

A molecular dynamics (MD) simulation, synthesis and very efficient hybridization for a series of N-acylated and N-alkylated derivatives of 2′-amino-LNA are reported.

Graphical abstract: Functionalized LNA (locked nucleic acid): high-affinity hybridization of oligonucleotides containing N-acylated and N-alkylated 2′-amino-LNA monomers

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Article information

DOI
https://doi.org/10.1039/B307026C
Article type
Communication
Submitted
19 Jun 2003
Accepted
14 Jul 2003
First published
28 Jul 2003

Chem. Commun., 2003, 2130-2131

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Functionalized LNA (locked nucleic acid): high-affinity hybridization of oligonucleotides containing N-acylated and N-alkylated 2′-amino-LNA monomers

M. D. Sørensen, M. Petersen and J. Wengel, Chem. Commun., 2003, 2130 DOI: 10.1039/B307026C

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