Issue 17, 2003
From the journal:

Chemical Communications

Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups

Toshiyuki Kan,a   Yusuke Tominari,a   Yuichi Morohashi,a   Hideaki Natsugari,a   Taisuke Tomita,a   Takeshi Iwatsuboa  and  Tohru Fukuyama*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
E-mail: fukuyama@mol.f.u-tokyo.ac.jp
Fax: +81-3-5802-8694
Tel: +81-3-5841-4777

Abstract

A benzophenone cross-linking group and a biotin-tag hybrid, resin 1a, attached to our novel resin 2 was readily converted to the photoaffnity probe 20 by condensation with the ligand carboxylic acid 19 and cleavage from the resin without purification.

Graphical abstract: Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups

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Article information

DOI
https://doi.org/10.1039/B306970B
Article type
Communication
Submitted
18 Jun 2003
Accepted
15 Jul 2003
First published
28 Jul 2003

Chem. Commun., 2003, 2244-2245

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Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups

T. Kan, Y. Tominari, Y. Morohashi, H. Natsugari, T. Tomita, T. Iwatsubo and T. Fukuyama, Chem. Commun., 2003, 2244 DOI: 10.1039/B306970B

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