Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling

Abstract

We review our recent work on adenosine receptors, a family of GPCRs; focusing our attention on A₃ adenosine receptor, we have demonstrated that the reciprocal integration of different theoretical and experimental disciplines can be very useful for the successful protein-based design of new, potent and selective receptor ligands.