Issue 11, 2003
From the journal:

Chemical Communications

Synthesis of HyBeacons and dual-labelled probes containing 2′-fluorescent groups for use in genetic analysis†

Neil Dobson,a   David G. McDowell,b   David J. French,b   Lynda J. Brown,c   John M. Mellora  and  Tom Brown*a  

* Corresponding authors

a Department of Chemistry, University of Southampton, Highfield, Southampton, UK
E-mail: tb2@soton.ac.uk
Fax: +44 (0)23 80592991
Tel: +44 (0)23 80592974

b LGC Ltd, Queens Road, Teddington, UK

c Oswel Research Products Ltd, Biological and Medical Sciences Building, University of Southampton, Boldrewood, Bassett Crescent East, Southampton, UK

Abstract

An FMOC-protected 2′-hydroxyethyl uridine phosphoramidite has been used to synthesise fluorescein-labelled HyBeacon probes and “FAM-ROX” dual-labelled fluorogenic oligonucleotides.

Graphical abstract: Synthesis of HyBeacons and dual-labelled probes containing 2′-fluorescent groups for use in genetic analysis

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Article information

DOI
https://doi.org/10.1039/B302855K
Article type
Communication
Submitted
13 Mar 2003
Accepted
03 Apr 2003
First published
07 May 2003

Chem. Commun., 2003, 1234-1235

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Synthesis of HyBeacons and dual-labelled probes containing 2′-fluorescent groups for use in genetic analysis

N. Dobson, D. G. McDowell, D. J. French, L. J. Brown, J. M. Mellor and T. Brown, Chem. Commun., 2003, 1234 DOI: 10.1039/B302855K

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