Efficient synthesis of globoside and isogloboside tetrasaccharides by using β(1→3)N-acetylgalactosaminyltransferase/UDP-N-acetylglucosamine C4 epimerase fusion protein

Jun Shao; Jianbo Zhang; Przemyslaw Kowal; Yuquan Lu; Peng George Wang

doi:10.1039/B300831B

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Efficient synthesis of globoside and isogloboside tetrasaccharides by using β(1→3) N-acetylgalactosaminyltransferase/UDP-N-acetylglucosamine C4 epimerase fusion protein†

Jun Shao,^a Jianbo Zhang,^a Przemyslaw Kowal,^a Yuquan Lu^a and Peng George Wang^a

Author affiliations

^a Department of Chemistry, Wayne State University, Detroit, MI 48202, USA
E-mail: pwang@chem.wayne.edu.
Fax: 313-577-2554
Tel: 313-993-6759

Abstract

The β(1→3) N-acetylgalactosaminyltransferase/UDP-N-acetylglucosamine C4 epimerase fusion protein was constructed and used in coupled enzymatic reactions to synthesize a variety of globotetraose and isoglobotetraose derivatives from the corresponding lactoside acceptors.

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Article information

DOI: https://doi.org/10.1039/B300831B
Article type: Communication
Submitted: 19 Feb 2003
Accepted: 07 Apr 2003
First published: 15 May 2003

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Chem. Commun., 2003, 1422-1423

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Efficient synthesis of globoside and isogloboside tetrasaccharides by using β(1→3) N-acetylgalactosaminyltransferase/UDP-N-acetylglucosamine C4 epimerase fusion protein

J. Shao, J. Zhang, P. Kowal, Y. Lu and P. G. Wang, Chem. Commun., 2003, 1422 DOI: 10.1039/B300831B

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