Issue 5, 2003
From the journal:

Chemical Communications

Novel isomenthone-derived 1,3-diol ligands identified through parallel synthesis and screening catalyse an asymmetric aldol reaction†

John M. Gardiner,*a   Philip D. Crewe,a   Gillian E. Smith‡b  and  Kenneth T. Vealb  

* Corresponding authors

a Department of Chemistry, UMIST, Sackville Street, Manchester, UK
E-mail: john.gardiner@umist.ac.uk
Fax: 001 510 217 2371
Tel: +44 (0)161 200 4530

b GlaxoSmithKline, New Frontiers Science Park, Essex, Harlow, UK
E-mail: gillian_e_smith@gsk.com

Abstract

A library of new (+)-isomenthone-derived 1,3-diol ligands, containing 5 contiguous stereocentres (3 fixed, 2 variable), was prepared in 2 steps by parallel synthesis. Evaluation in parallel identified several different ligands from the library for catalysing a Mukaiyama aldol reaction with 87–90% e.e.

Graphical abstract: Novel isomenthone-derived 1,3-diol ligands identified through parallel synthesis and screening catalyse an asymmetric aldol reaction

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Article information

DOI
https://doi.org/10.1039/B212769P
Article type
Communication
Submitted
23 Dec 2002
Accepted
24 Jan 2003
First published
06 Feb 2003

Chem. Commun., 2003, 618-619

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Novel isomenthone-derived 1,3-diol ligands identified through parallel synthesis and screening catalyse an asymmetric aldol reaction

J. M. Gardiner, P. D. Crewe, G. E. Smith and K. T. Veal, Chem. Commun., 2003, 618 DOI: 10.1039/B212769P

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