Employing the simple monosilylcopper reagent, Li[PhMe2SiCuI], in 1,4-addition reactions

Jesse Dambacher; Mikael Bergdahl

doi:10.1039/B210792A

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Employing the simple monosilylcopper reagent, Li[PhMe₂SiCuI], in 1,4-addition reactions†

Jesse Dambacher^a and Mikael Bergdahl*^a

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* Corresponding authors

^a Department of Chemistry, San Diego State University, San Diego, CA, USA
E-mail: bergdahl@sciences.sdsu.edu

Abstract

Conjugate addition reactions using the simple Li[PhMe₂SiCuI] reagent to a variety of α,β-unsaturated carbonyl compounds is described; dimethyl sulfide from the purification of CuI plays a key role for very high yields as well as high stereoselectivities in the formation of β-silyl carbonyl compounds.

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Supplementary files

Typical experimental procedure, ¹H-NMR, ¹³C-NMR, MS, and IR spectral data for all beta-silyl carbonyl compounds PDF (4644K)

Article information

DOI: https://doi.org/10.1039/B210792A
Article type: Communication
Submitted: 30 Oct 2002
Accepted: 19 Nov 2002
First published: 03 Dec 2002

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Chem. Commun., 2003, 144-145

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Employing the simple monosilylcopper reagent, Li[PhMe₂SiCuI], in 1,4-addition reactions

J. Dambacher and M. Bergdahl, Chem. Commun., 2003, 144 DOI: 10.1039/B210792A

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