Issue 11, 2003
From the journal:

Chemical Communications

Ruthenium complexes carrying a disialo complex-type oligosaccharide: enzymatic synthesis and its application to a luminescent probe to detect influenza viruses†

Shinji Kojima,a   Teruaki Hasegawa,a   Takahiro Yonemura,a   Ken Sasaki,b   Kenji Yamamoto,c   Yutaka Makimura,c   Tadanobu Takahashi,de   Takashi Suzuki,de   Yasuo Suzukide  and  Kazukiyo Kobayashi*ae  

* Corresponding authors

a Department of Molecular Design and Department of Biotechnology, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan
E-mail: kobayash@mol.nagoya-u.ac.jp
Fax: +81-52-789-2528

b Central Research Laboratory, Taiyo Kagaku Co., Ltd., Yokkaichi 510-0844, Japan

c Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan

d University of Shizuoka School of Pharmaceutical Sciences, Shizuoka 422-8526, Japan

e CREST, Japan Science and Technology Corporation (JST), 4-1-8 Hon-cho, Kawaguchi, Japan

Abstract

Tris-bipyridine ruthenium-complexes carrying a disialo complex-type oligosaccharide were prepared via a one-pot transglycosylation using endo-glycosidase (Endo M); they bind to type-A influenza viruses with excellent affinity (IC50 = 8.4 µM), and their luminescence intensity is strongly depressed by virus-binding.

Graphical abstract: Ruthenium complexes carrying a disialo complex-type oligosaccharide: enzymatic synthesis and its application to a luminescent probe to detect influenza viruses

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Article information

DOI
https://doi.org/10.1039/B210739B
Article type
Communication
Submitted
31 Oct 2002
Accepted
24 Mar 2003
First published
23 Apr 2003

Chem. Commun., 2003, 1250-1251

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Ruthenium complexes carrying a disialo complex-type oligosaccharide: enzymatic synthesis and its application to a luminescent probe to detect influenza viruses

S. Kojima, T. Hasegawa, T. Yonemura, K. Sasaki, K. Yamamoto, Y. Makimura, T. Takahashi, T. Suzuki, Y. Suzuki and K. Kobayashi, Chem. Commun., 2003, 1250 DOI: 10.1039/B210739B

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