Peptide nucleic acids: structure, properties, applications, strategies and practice of chemical synthesis

Abstract

The information on the structure and properties of peptide nucleic acids (PNA) is generalised. The use of PNA oligomers in biomolecular studies and biotechnology is exemplified. The published data on the most important methods for the chemical synthesis of PNA oligomers with the main emphasis on the efficiency of condensation reactions are considered. The methods for PNA synthesis are systematised; their advantages and disadvantages are discussed. Some recommendations for optimisation of the condensation procedure and synthesis of PNA are presented. The bibliography includes 153 references.