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Issue 10, 2002
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New insights into the oxidation pathways of apomorphine

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Abstract

A detailed study of the oxidative behaviour of apomorphine in aqueous media is reported. Resorting to the synthesis of apomorphine derivatives it was possible to identify all the anodic oxidation peaks of apomorphine, which are related to the oxidation of the catechol and tertiary amine groups. These findings were revealed to be important since they could lead to a better understanding of the biological interactions of apomorphine and gain insight into its metabolic pathways. During the voltammetric studies, it was also found that apomorphine forms a complex with borate through the catechol group leading to an increase of its oxidation potential. This property could be very useful with regard to the stabilization of apomorphine solutions since it could drastically reduce its autoxidation.

Graphical abstract: New insights into the oxidation pathways of apomorphine

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Article information


Submitted
14 May 2002
Accepted
30 Jul 2002
First published
23 Aug 2002

J. Chem. Soc., Perkin Trans. 2, 2002, 1713-1717
Article type
Paper

New insights into the oxidation pathways of apomorphine

J. M. P. J. Garrido, C. Delerue-Matos, F. Borges, T. R. A. Macedo and A. M. Oliveira-Brett, J. Chem. Soc., Perkin Trans. 2, 2002, 1713
DOI: 10.1039/B204605A

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