Jump to main content
Jump to site search

Issue 22, 2002
Previous Article Next Article

A chemoenzymatic synthesis of (−)-hirsutene from toluene

Author affiliations

Abstract

The enantiomerically pure cis-1,2-diol 2, which is obtained by microbial oxidation of toluene, has been converted, via a sequence of reactions including high-pressure promoted Diels–Alder cycloaddition and oxa-di-π-methane rearrangement steps, into the triquinane (−)-hirsutene (1).

Graphical abstract: A chemoenzymatic synthesis of (−)-hirsutene from toluene

Back to tab navigation

Supplementary files

Article information


Submitted
12 Sep 2002
Accepted
18 Oct 2002
First published
28 Oct 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 2439-2441
Article type
Communication

A chemoenzymatic synthesis of (−)-hirsutene from toluene

M. G. Banwell, A. J. Edwards, G. J. Harfoot and K. A. Jolliffe, J. Chem. Soc., Perkin Trans. 1, 2002, 2439
DOI: 10.1039/B208778B

Search articles by author

Spotlight

Advertisements