Issue 20, 2002

A mild, enantioselective synthesis of (R)-salmeterolvia sodium borohydride–calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative

Abstract

A short and efficient enantioselective route to (R)-salmeterol involving asymmetric reduction of a phenylglycinyl ketone derivative followed by reductive amination of the resulting amino alcohol and hydrogenolysis is described.

Graphical abstract: A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride–calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative

Supplementary files

Article information

Article type
Paper
Submitted
18 Jul 2002
Accepted
28 Aug 2002
First published
18 Sep 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 2237-2242

A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride–calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative

R. N. Bream, S. V. Ley, B. McDermott and P. A. Procopiou, J. Chem. Soc., Perkin Trans. 1, 2002, 2237 DOI: 10.1039/B207068P

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