Issue 19, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Palladium-catalyzed tandem C,N-arylation of immobilized enamine for solid phase indole synthesis†

Kazuo Yamazaki,‡a   Yosuke Nakamuraa  and  Yoshinori Kondo*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980–8578, Japan
E-mail: ykondo@mail.pharm.tohoku.ac.jp
Fax: 022–217–6804
Tel: 022–217–6804

Abstract

Intramolecular palladium-catalyzed N-arylation of immobilized dehydrohalophenylalaninate was found to proceed smoothly to form indolecarboxylates. The method was successfully combined with the Heck reaction to perform one pot indole synthesis via palladium-catalyzed tandem C,N-arylation reactions.

Graphical abstract: Palladium-catalyzed tandem C,N-arylation of immobilized enamine for solid phase indole synthesis

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Article information

DOI
https://doi.org/10.1039/B206378F
Article type
Communication
Submitted
02 Jul 2002
Accepted
22 Aug 2002
First published
30 Aug 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 2137-2138

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Palladium-catalyzed tandem C,N-arylation of immobilized enamine for solid phase indole synthesis

K. Yamazaki, Y. Nakamura and Y. Kondo, J. Chem. Soc., Perkin Trans. 1, 2002, 2137 DOI: 10.1039/B206378F

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