The synthesis of benzylphosphine oxides via vicarious nucleophilic substitution and alkenes via VNS–Horner–Wittig reactions
Abstract
A range of substituted nitrobenzenes react with the anion of (chloromethyl)diphenylphosphinoyl oxide to give the substituted nitrobenzyldiphenylphosphine oxide by vicarious nucleophilic substitution. The novel stereoselective synthesis of E–stilbenes via a one–pot vicarious nucleophilic substitution–Horner–Wittig reaction is described.