Synthesis of 2′,3′-didehydro-2′,3′-dideoxy-2′-fluoro apionucleosides as potential antiviral agents

Abstract

Synthesis of novel 2′,3′-didehydro-2′,3′-dideoxy-2′-fluoro apionucleosides which combine the properties of 2′,3′-didehydro-2′,3′-dideoxy nucleosides and apionucleosides on the basis of a bioisosteric rationale is described.