Issue 11, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthetic studies on CP-225,917 and CP-263,114: concise synthesis of the bicyclic core using an intramolecular Mukaiyama aldol reaction†

Alan Armstrong,‡*ab   Trevor J. Critchley,a   Marie-Edith Gourdel-Martin,a   Richard D. Kelseyb  and  Andrew A. Mortlockc  

* Corresponding authors

a School of Chemistry, University of Nottingham, Nottingham, UK

b Department of Chemistry, Imperial College, London, UK

c AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, UK

Abstract

A concise synthesis of the bicyclo[4.3.1]dec-1(9)-en-10-one core of the natural products CP-225,917 and CP-263,114 is reported, employing an intramolecular Mukaiyama aldol cyclisation as a key step.

Graphical abstract: Synthetic studies on CP-225,917 and CP-263,114: concise synthesis of the bicyclic core using an intramolecular Mukaiyama aldol reaction

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Article information

DOI
https://doi.org/10.1039/B202752F
Article type
Paper
Submitted
19 Mar 2002
Accepted
10 Apr 2002
First published
01 May 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 1344-1350

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Synthetic studies on CP-225,917 and CP-263,114: concise synthesis of the bicyclic core using an intramolecular Mukaiyama aldol reaction

A. Armstrong, T. J. Critchley, M. Gourdel-Martin, R. D. Kelsey and A. A. Mortlock, J. Chem. Soc., Perkin Trans. 1, 2002, 1344 DOI: 10.1039/B202752F

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