Issue 10, 2002

A convenient general synthesis of 3-substituted 2H-chromene derivatives

Abstract

Reactions of 2-hydroxybenzaldehydes and 2-hydroxy-1-naphthaldehydes with various activated alkenes under Baylis–Hillman conditions have been shown to proceed with regioselective cyclisation to afford the corresponding 3-substituted chromene derivatives. In some cases competitive dimerisation of the alkene component was observed, and direct dimerisation in the absence of the aldehyde has been explored.

Graphical abstract: A convenient general synthesis of 3-substituted 2H-chromene derivatives

Article information

Article type
Paper
Submitted
20 Feb 2002
Accepted
02 Apr 2002
First published
26 Apr 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 1318-1323

A convenient general synthesis of 3-substituted 2H-chromene derivatives

P. T. Kaye and X. W. Nocanda, J. Chem. Soc., Perkin Trans. 1, 2002, 1318 DOI: 10.1039/B201827F

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