Synthesis, X-ray crystal structures and Horner–Wittig addition reactions of some protected β-aminophosphine oxides

Abstract

Several protected β-aminophosphine oxides have been synthesised and investigated in the Horner–Wittig addition reaction. Crystal structures of an enantiomerically pure β-amino phosphine oxide and a Horner–Wittig addition product are presented. Horner–Wittig reactions were typically poorly stereoselective, although the ratio of diastereoisomers can be influenced by the addition of lithium bromide.