Issue 8, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Total synthesis of naamine C and pyronaamidine, antitumor marine imidazolealkaloids

Seikou Nakamura,a   Ikuo Kawasaki,a   Miki Kunimura,a   Miyuki Matsui,a   Yoko Noma,a   Masayuki Yamashitaa  and  Shunsaku Ohta*a  

* Corresponding authors

a Kyoto Pharmaceutical University, Misasagi Yamashinaku, Kyoto 607-8414, Japan
E-mail: sohta@mb.kyoto-phu.ac.jp

Abstract

The first total synthesis of naamine C and pyronaamidine, highly substituted and cytotoxic imidazole marine alkaloids of a certain kind of sponge, was achieved through an eight-step reaction starting from 1-methyl-2-phenylthio-1H-imidazole.

Graphical abstract: Total synthesis of naamine C and pyronaamidine, antitumor marine imidazole alkaloids

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Article information

DOI
https://doi.org/10.1039/B200845A
Article type
Paper
Submitted
23 Jan 2002
Accepted
06 Mar 2002
First published
19 Mar 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 1061-1066

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Total synthesis of naamine C and pyronaamidine, antitumor marine imidazole alkaloids

S. Nakamura, I. Kawasaki, M. Kunimura, M. Matsui, Y. Noma, M. Yamashita and S. Ohta, J. Chem. Soc., Perkin Trans. 1, 2002, 1061 DOI: 10.1039/B200845A

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