Issue 4, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Substitution of α-azido ethers with Grignard reagents and its use in combinatorial chemistry

Mukulesh Baruaha  and  Mikael Bols*a  

* Corresponding authors

a Department of Chemistry, University of Aarhus, Langelandsgade 140 Aarhus C, DK-8000, Denmark
E-mail: mb@kemi.aau.dk

Abstract

α-Azidobenzyl ethers were reacted with alkyl or arylGrignard reagents in toluene to produce α-alkylbenzyl or diarylmethyl ethers in 82–94% yield. α-Azidobenzyl ethers were also reacted with multicomponent Grignard reagents to produce libraries of α-alkylbenzyl ethers.

Graphical abstract: Substitution of α-azido ethers with Grignard reagents and its use in combinatorial chemistry

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Article information

DOI
https://doi.org/10.1039/B110428B
Article type
Paper
Submitted
14 Nov 2001
Accepted
07 Jan 2002
First published
22 Jan 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 509-512

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Substitution of α-azido ethers with Grignard reagents and its use in combinatorial chemistry

M. Baruah and M. Bols, J. Chem. Soc., Perkin Trans. 1, 2002, 509 DOI: 10.1039/B110428B

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