Issue 1, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

A chemoenzymatic synthesis of the 12-membered macrolide (−)-cladospolide A

Martin G. Banwell,*a   Katrina A. Jolliffe,a   David T. J. Loong,a   Kenneth J. McRaea  and  Filisaty Vounatsosa  

* Corresponding authors

a Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia
E-mail: mgb@rsc.anu.edu.au

Abstract

The enantiomerically pure cis-1,2-dihydrocatechol 7, which is obtained by microbial oxidation of chlorobenzene, has been converted, via a sequence of reactions including ring-closing metathesis and Yamaguchi lactonisation steps, into the natural product (−)-cladospolide A (1).

Graphical abstract: A chemoenzymatic synthesis of the 12-membered macrolide (−)-cladospolide A

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Article information

DOI
https://doi.org/10.1039/B110018A
Article type
Communication
Submitted
05 Nov 2001
Accepted
14 Nov 2001
First published
03 Dec 2001

J. Chem. Soc., Perkin Trans. 1, 2002, 22-25

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A chemoenzymatic synthesis of the 12-membered macrolide (−)-cladospolide A

M. G. Banwell, K. A. Jolliffe, D. T. J. Loong, K. J. McRae and F. Vounatsos, J. Chem. Soc., Perkin Trans. 1, 2002, 22 DOI: 10.1039/B110018A

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