Issue 2, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Two novel racemic synthetic approaches to LTB4 and LTB3 methyl esters

Christine Gauthier,a   Dominique Castet,a   Yvan Ramondenca  and  Gérard Plé*a  

* Corresponding authors

a Université de Rouen, IRCOF, UMR 6014, F-76821 Mont Saint Aignan, France
E-mail: Gerard.Ple@univ-rouen.fr
Fax: 33-2/35522971
Tel: 33-2/35522448

Abstract

The formal racemic synthesis of LTB4 and LTB3 methyl esters 1 and 2 is reported by introducing in a one step-procedure the E,E,Z-conjugated trienic system provided by (1E,3E,5Z)-1,6-dibromohexa-1,3,5-triene 3 and (1E,3E,5Z)-1-bromo-7,7-diethoxyhepta-1,3,5-triene 4, respectively, as building blocks.

Graphical abstract: Two novel racemic synthetic approaches to LTB4 and LTB3 methyl esters

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Article information

DOI
https://doi.org/10.1039/B108847E
Article type
Paper
Submitted
02 Oct 2001
Accepted
21 Nov 2001
First published
18 Dec 2001

J. Chem. Soc., Perkin Trans. 1, 2002, 191-196

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Two novel racemic synthetic approaches to LTB4 and LTB3 methyl esters

C. Gauthier, D. Castet, Y. Ramondenc and G. Plé, J. Chem. Soc., Perkin Trans. 1, 2002, 191 DOI: 10.1039/B108847E

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