Issue 3, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

α-Chymotrypsin-catalysed segment condensations via the kinetically controlled approach using carbamoylmethyl esters as acyl donors in organic media†

Toshifumi Miyazawa,*a   Eiichi Ensatsu,a   Makoto Hiramatsu,a   Ryoji Yanagiharaa  and  Takashi Yamadaa  

* Corresponding authors

a Department of Chemistry, Faculty of Science and Engineering, Konan University, Higashinada-ku, Kobe 658-8501, Japan

Abstract

The superiority of the carbamoylmethyl ester as an acyl donor for the α-chymotrypsin-catalysed segment condensations via the kinetically controlled approach is demonstrated in several model systems carried out in organic media with low water content. Furthermore, this approach is successfully applied to the construction of the Leu-enkephalin sequence via a 4 + 1 segment coupling.

Graphical abstract: α-Chymotrypsin-catalysed segment condensations via the kinetically controlled approach using carbamoylmethyl esters as acyl donors in organic media

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Article information

DOI
https://doi.org/10.1039/B108738J
Article type
Paper
Submitted
25 Sep 2001
Accepted
27 Nov 2001
First published
08 Jan 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 396-401

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α-Chymotrypsin-catalysed segment condensations via the kinetically controlled approach using carbamoylmethyl esters as acyl donors in organic media

T. Miyazawa, E. Ensatsu, M. Hiramatsu, R. Yanagihara and T. Yamada, J. Chem. Soc., Perkin Trans. 1, 2002, 396 DOI: 10.1039/B108738J

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