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Issue 1, 2002
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Diastereocontrolled synthesis of hydroxylated lactams

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Abstract

Highly diastereoselective reductions and organometallic additions in bicyclic lactams have been observed, which appear to result either from a stereoelectronic interaction of the pyramidalised nitrogen lone pair or from steric interactions in the bicyclic system. These products can be readily deprotected to give hydroxylated lactams.

Graphical abstract: Diastereocontrolled synthesis of hydroxylated lactams

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Publication details

The article was received on 05 Sep 2001, accepted on 02 Nov 2001 and first published on 05 Dec 2001


Article type: Paper
DOI: 10.1039/B108056N
J. Chem. Soc., Perkin Trans. 1, 2002, 80-90

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    Diastereocontrolled synthesis of hydroxylated lactams

    Mark. D. Andrews, A. G. Brewster and M. G. Moloney, J. Chem. Soc., Perkin Trans. 1, 2002, 80
    DOI: 10.1039/B108056N

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