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Issue 2, 2002
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Impact of the peptide sequence on the coordination abilities of albumin-like tripeptides towards Cu2+, Ni2+ and Zn2+ ions. Potential albumin-like peptide chelators

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Abstract

Thermodynamic and spectroscopic studies have shown that the insertion of α-hydroxylmethylserine (HmS) residues into the N-terminal peptide motif of human serum albumin results in a very powerful chelating agent for Cu2+ and Ni2+ ions. The insertion of two HmS residues results in the HmS–HmS–His–OH/NH2 sequence, which is the most effective chelating agent based on an albumin-like sequence for both studied metal ions, especially when the C-terminal carboxylate is protected by an amide function.

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Article information


Submitted
13 Aug 2001
Accepted
09 Oct 2001
First published
07 Feb 2002

New J. Chem., 2002,26, 264-268
Article type
Paper

Impact of the peptide sequence on the coordination abilities of albumin-like tripeptides towards Cu2+, Ni2+ and Zn2+ ions. Potential albumin-like peptide chelators

P. Mlynarz, D. Valensin, K. Kociolek, J. Zabrocki, J. Olejnik and H. Kozlowski, New J. Chem., 2002, 26, 264
DOI: 10.1039/B107412C

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