Pd-catalysed coupling reactions in supercritical carbon dioxide and under solventless conditions

Abstract

The homocoupling of iodoarenes catalysed by Pd(OCOCF₃)₂/P(2-furyl)₃ occurs best in scCO₂ and under solventless reaction conditions, and provides an attractive alternative to previously reported procedures. A comparison of the results in these cases suggests interesting preferential solvation effects are occurring in scCO₂. Each of the methods investigated has advantages and disadvantages which need to be carefully considered before the method of choice is determined.