Issue 8, 2002

Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group

Abstract

Synthesis of short peptides using propargyloxycarbonyl amino acid chlorides as effective coupling reagents and polymer supported tetrathiomolybdate as an efficient deblocking agent are reported.

Graphical abstract: Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group

Article information

Article type
Communication
Submitted
07 Jan 2002
Accepted
26 Feb 2002
First published
13 Mar 2002

Chem. Commun., 2002, 812-813

Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group

R. G. Bhat, S. Sinha and S. Chandrasekaran, Chem. Commun., 2002, 812 DOI: 10.1039/B200155A

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