Issue 23, 2002
From the journal:

Chemical Communications

Asymmetric synthesis of (1R,2S,3R)-γ-methyl-cis-pentacin by a kinetic resolution protocol

Simon Bailey,b   Stephen G. Davies,*a   Andrew D. Smitha  and  Jonathan M. Witheya  

* Corresponding authors

a The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK
E-mail: steve.davies@chemistry.oxford.ac.uk

b Discovery Chemistry, IPC 818, Pfizer Global Research and Development, Sandwich, Kent, UK

Abstract

The asymmetric synthesis of (1R,2S,3R)-3-methyl-2-aminocyclopentane carboxylic acid has been achieved via kinetic resolution of racemic tert-butyl 3-methyl-cyclopentene-1-carboxylate with homochiral lithium (S)-N-benzyl-N-α-methylbenzylamide.

Graphical abstract: Asymmetric synthesis of (1R,2S,3R)-γ-methyl-cis-pentacin by a kinetic resolution protocol

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Article information

DOI
https://doi.org/10.1039/B209728C
Article type
Communication
Submitted
03 Oct 2002
Accepted
22 Oct 2002
First published
05 Nov 2002

Chem. Commun., 2002, 2910-2911

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Asymmetric synthesis of (1R,2S,3R)-γ-methyl-cis-pentacin by a kinetic resolution protocol

S. Bailey, S. G. Davies, A. D. Smith and J. M. Withey, Chem. Commun., 2002, 2910 DOI: 10.1039/B209728C

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