Steric hindrance to the solvation of melamines and consequences for non-covalent synthesis

Abstract

Steric hindrance to solvation disfavors structures like 1syn-anti in which the melamine exposes to the solvent faces, such as tBu–H, for whom binding to the ring nitrogen is hindered but not blocked; steric hindrance to solvation lowers the barriers to rotation in solvents which bind the triazine nitrogens, therefore these solvents display the fastest rates for assembling/disassembling processes.