Issue 18, 2002

Efficient synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative bearing a spirolactone via a Diels–Alder reaction with high π-facial selectivity: a synthetic study towards scyphostatin

Abstract

The Diels–Alder reaction of spirolactones with cyclopentadiene afforded the adduct with high π-facial selectivity; a hydrophilic analogue of scyphostatin was synthesized from the Diels–Alder adduct.

Graphical abstract: Efficient synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative bearing a spirolactone via a Diels–Alder reaction with high π-facial selectivity: a synthetic study towards scyphostatin

Article information

Article type
Communication
Submitted
27 Jun 2002
Accepted
01 Aug 2002
First published
19 Aug 2002

Chem. Commun., 2002, 2096-2097

Efficient synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative bearing a spirolactone via a Diels–Alder reaction with high π-facial selectivity: a synthetic study towards scyphostatin

R. Takagi, W. Miyanaga, Y. Tamura and K. Ohkata, Chem. Commun., 2002, 2096 DOI: 10.1039/B206163E

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