It is demonstrated in this report that the authentic molecular structure of antibiotic varacin is capable of causing DNA-cleavage with high efficiency in the presence of thiols. In addition, it is found that the DNA-cleaving activity by varacin is apparently promoted by its acidic environments.
A. H. F. Lee, A. S. C. Chan and T. Li, Chem. Commun., 2002, 2112 DOI: 10.1039/B204920C
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