Issue 19, 2002
From the journal:

Chemical Communications

Quantitative determination of the enantiomeric composition of thalidomide solutions by electrospray ionizationtandem mass spectrometry

Daniella V. Augusti,ab   Rodinei Augusti,ab   Fernando Carazzab  and  R. Graham Cooks*a  

* Corresponding authors

a Department of Chemistry, Purdue University, West Lafayette, IN, USA
E-mail: cooks@purdue.edu
Fax: 1-765-494-0239
Tel: 1-765-494-5262

b Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Fax: 55-31-3499-5700
Tel: 55-31-3499-5725

Abstract

Rapid and simple chiral analysis of thalidomide solutions is demonstrated by using electrospray ionization tandem mass spectrometry and analysis of cluster ion dissociation by the kinetic method. Average deviations of 1% between the actual and experimental enantiomeric compositions are observed.

Graphical abstract: Quantitative determination of the enantiomeric composition of thalidomide solutions by electrospray ionization tandem mass spectrometry

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Article information

DOI
https://doi.org/10.1039/B204421H
Article type
Communication
Submitted
09 May 2002
Accepted
22 Aug 2002
First published
09 Sep 2002

Chem. Commun., 2002, 2242-2243

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Quantitative determination of the enantiomeric composition of thalidomide solutions by electrospray ionization tandem mass spectrometry

D. V. Augusti, R. Augusti, F. Carazza and R. G. Cooks, Chem. Commun., 2002, 2242 DOI: 10.1039/B204421H

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