Issue 17, 2002
From the journal:

Chemical Communications

Synthesis of an l-proline modified mimetic of the A83586C antitumour cyclodepsipeptide†

Karl J. Hale*a  and  Linos Lazaridesa  

* Corresponding authors

a The Christopher Ingold Laboratories, The Department of Chemistry, University College London, 20 Gordon Street, London, UK
E-mail: k.j.hale@ucl.ac.uk

Abstract

A mimetic of the A83586C cyclodepsipeptide has been synthesised via a three-segment coupling protocol involving dipeptides 9, 8 and 7; in contrast to our previous synthesis of A83586C, where the HATU-mediated macrolactamisation proceeded in 25% yield, the corresponding macro-lactamisation of seco-amino acid 18 occurred in ca. 78% yield.

Graphical abstract: Synthesis of an l-proline modified mimetic of the A83586C antitumour cyclodepsipeptide

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Article information

DOI
https://doi.org/10.1039/B204018B
Article type
Communication
Submitted
26 Apr 2002
Accepted
01 Jul 2002
First published
19 Jul 2002

Chem. Commun., 2002, 1832-1833

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Synthesis of an L-proline modified mimetic of the A83586C antitumour cyclodepsipeptide

K. J. Hale and L. Lazarides, Chem. Commun., 2002, 1832 DOI: 10.1039/B204018B

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