Issue 14, 2002
From the journal:

Chemical Communications

A new approach to functionalised spiropiperidines through tandem RCM and nitrogen-directed reactions†

Andrew S. Edwards,a   Robert A. J. Wybrow,a   Craig Johnstone,b   Harry Adamsa  and  Joseph P. A. Harrity*a  

* Corresponding authors

a Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, UK
E-mail: j.harrity@sheffield.ac.uk

b Department of Medicinal Chemistry, AstraZeneca, Mereside, Cheshire, Alderley Park, UK

Abstract

The synthesis of a functionalised spiropiperidine via a tandem ring closing metathesis strategy is described, furthermore, the regio- and stereoselective functionalisation of this compound has been achieved through a novel nitrogen-directed epoxidation reaction.

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Article information

DOI
https://doi.org/10.1039/B203851J
Article type
Communication
Submitted
19 Apr 2002
Accepted
29 May 2002
First published
18 Jun 2002

Chem. Commun., 2002, 1542-1543

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A new approach to functionalised spiropiperidines through tandem RCM and nitrogen-directed reactions

A. S. Edwards, R. A. J. Wybrow, C. Johnstone, H. Adams and J. P. A. Harrity, Chem. Commun., 2002, 1542 DOI: 10.1039/B203851J

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