Labelling of [Leu5]-enkephalin with organometallic Mo complexes by solid-phase synthesis

Abstract

The neuropeptide leucine-enkephalin ([Leu⁵]-enkephalin) has been covalently labelled with the two organometallic Mo carbonyl complexes Mo(R-His)(allyl)(CO)₂ (His = N_δ,N,O-L-histidinate) and Mo(R-bpa)(CO)₃ (bpa = bis(2-picolyl)amine) on the resin as the last step of a solid-phase synthesis scheme and in solution.