Issue 10, 2002
From the journal:

Chemical Communications

New stereoselective reaction of methylglyoxal with 2-aminopyridine and adenine derivatives: Formation of imino acid-nucleic base derivatives in water under mild conditions

Christel Routaboul,a   Lionel Dumas,a   Isabelle Gautier-Luneau,b   Jacques Vergne,c   Marie-Christine Maurelc  and  Jean-Luc Décout*a  

* Corresponding authors

a Laboratoire de Chimie Bio-organique, Département de Pharmacochimie Moléculaire, UMR 5063 CNRS/Université Joseph Fourier-Grenoble I, Domaine de la Merci, La Tronche Cedex, France
E-mail: Jean-Luc.Decout@ujf-grenoble.fr
Fax: 33 4 76 04 10 07
Tel: 33 4 76 63 74 57

b LEDSS 2, UMR 5616 CNRS/Université Joseph Fourier-Grenoble I, BP53, Grenoble Cedex 9, France
Fax: 33 4 76 51 42 51
Tel: 33 4 76 51 44 67

c Laboratoire Biochimie de l′Evolution et Adaptabilité moléculaire, Institut Jacques Monod, Tour 43, 2 place Jussieu, Paris Cedex 05, France
Fax: 33 1 44 27 40 21
Tel: 33 1 44 27 59 94

Abstract

A remarkable stereoselective reaction of methylglyoxal with 2-aminopyridine, the nucleic base adenine and adenine nucleosides leads in good yield to heterocycles of a new family in water under mild conditions and should be of interest in the understanding of the biological effects of methylglyoxal which is toxic, mutagenic and involved in diabetic complications.

Graphical abstract: New stereoselective reaction of methylglyoxal with 2-aminopyridine and adenine derivatives: Formation of imino acid-nucleic base derivatives in water under mild conditions

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B201901A
Article type
Communication
Submitted
25 Feb 2002
Accepted
05 Apr 2002
First published
23 Apr 2002

Chem. Commun., 2002, 1114-1115

Permissions

Request permissions

New stereoselective reaction of methylglyoxal with 2-aminopyridine and adenine derivatives: Formation of imino acid-nucleic base derivatives in water under mild conditions

C. Routaboul, L. Dumas, I. Gautier-Luneau, J. Vergne, M. Maurel and J. Décout, Chem. Commun., 2002, 1114 DOI: 10.1039/B201901A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements