Issue 10, 2002

New stereoselective reaction of methylglyoxal with 2-aminopyridine and adenine derivatives: Formation of imino acid-nucleic base derivatives in water under mild conditions

Abstract

A remarkable stereoselective reaction of methylglyoxal with 2-aminopyridine, the nucleic base adenine and adenine nucleosides leads in good yield to heterocycles of a new family in water under mild conditions and should be of interest in the understanding of the biological effects of methylglyoxal which is toxic, mutagenic and involved in diabetic complications.

Graphical abstract: New stereoselective reaction of methylglyoxal with 2-aminopyridine and adenine derivatives: Formation of imino acid-nucleic base derivatives in water under mild conditions

Supplementary files

Article information

Article type
Communication
Submitted
25 Feb 2002
Accepted
05 Apr 2002
First published
23 Apr 2002

Chem. Commun., 2002, 1114-1115

New stereoselective reaction of methylglyoxal with 2-aminopyridine and adenine derivatives: Formation of imino acid-nucleic base derivatives in water under mild conditions

C. Routaboul, L. Dumas, I. Gautier-Luneau, J. Vergne, M. Maurel and J. Décout, Chem. Commun., 2002, 1114 DOI: 10.1039/B201901A

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