Issue 8, 2002
From the journal:

Chemical Communications

A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes†

Paul H. Schlesinger,*b   Riccardo Ferdani,a   Robert Pajewski,a   Jolanta Pajewskaa  and  George W. Gokel*a  

* Corresponding authors

a Division of Bioorganic Chemistry, Bioorganic Chemistry Program and Department of Molecular Biology & Pharmacology, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8103, St. Louis, MO, USA

b Department of Cell Biology, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8103, St. Louis, MO, USA
E-mail: ggokel@molecool.wustl.edu
Fax: 314/362-9298 or 7058
Tel: 314/362-9297

Abstract

The heptapeptide sequence Gly-Gly-Gly-Pro-Gly-Gly-Gly, when anchored to diglycolic acid derived (C18H37)2NCOCH2OCH2COOH, forms chloride-selective ion channels in phospholipid liposomes but the related heptapeptide Gly-Gly-Gly-Leu-Gly-Gly-Gly, and tripeptide Gly-Gly-Gly do not.

Graphical abstract: A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes

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Article information

DOI
https://doi.org/10.1039/B200126H
Article type
Communication
Submitted
17 Dec 2001
Accepted
13 Feb 2002
First published
19 Mar 2002

Chem. Commun., 2002, 840-841

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A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes

P. H. Schlesinger, R. Ferdani, R. Pajewski, J. Pajewska and G. W. Gokel, Chem. Commun., 2002, 840 DOI: 10.1039/B200126H

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