Synthesis of d-erythro-sphingosine and d-erythro-ceramide
Abstract
A 1,2-metallate rearrangment of a higher order cuprate derived from an α-lithiated xylal derivative and tridecyllithium is the key step in a synthesis of D-erythro-sphingosine and ceramide. A convenient method for preparing α-lithiated glycals from α-phenylsulfinyl glycals is also described.