Issue 5, 2002
From the journal:

Chemical Communications

Oligodeoxynucleotides containing amide-linked LNA-type dinucleotides: synthesis and high-affinity nucleic acid hybridization

Anne Lauritsena  and  Jesper Wengel*b  

* Corresponding authors

a Department of Chemistry, University of Copenhagen, Universitetsparken 5, Copenhagen, Denmark

b Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, Odense M, Denmark
E-mail: jwe@chem.sdu.dk

Abstract

Synthesis of three different amide-linked LNA-type dinucleotides and their incorporation into 9-mer and 17-mer oligodeoxynucleotides is described; compared to the reference DNA–RNA duplex, incorporation of one of the three dimers (5′-DNA*LNA dimer) induced significantly increased duplex thermostabilities.

Graphical abstract: Oligodeoxynucleotides containing amide-linked LNA-type dinucleotides: synthesis and high-affinity nucleic acid hybridization

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Article information

DOI
https://doi.org/10.1039/B111000D
Article type
Communication
Submitted
06 Dec 2001
Accepted
29 Jan 2002
First published
12 Feb 2002

Chem. Commun., 2002, 530-531

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Oligodeoxynucleotides containing amide-linked LNA-type dinucleotides: synthesis and high-affinity nucleic acid hybridization

A. Lauritsen and J. Wengel, Chem. Commun., 2002, 530 DOI: 10.1039/B111000D

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