A simple and practical method to make chiral propargylic alcohols has been developed: in the presence of a titanium alkoxide catalyst prepared in situ from titanium tetraisopropoxide and (R)-H8-binaphthol, a variety of aromatic aldehydes were converted to the corresponding chiral propargylic alcohols with very good enantioselectivities (up to 96.2% e.e.) and yields.
G. Lu, X. Li, W. L. Chan and A. S. C. Chan, Chem. Commun., 2002, 172 DOI: 10.1039/B107817H
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