Preparation and structural properties of dithia[3.3.1]metacyclophanes

Abstract

Various substituents have been introduced into the inner or the outer position of the dithia[3.3.1]metacyclophanes (MCPs). Conformational properties of these MCPs are evaluated by variable temperature ¹H-NMR spectral measurements, IR measurements, computer calculation and X-ray structural analyses. It has been found that the conformations of dithia[3.3.1]MCPs are affected by not only the steric effect of the inner or the outer substituent but also by the electronic nature of the component aromatic ring. Furthermore, a weak interaction such as NH–π interaction or hydrogen-bonding also regulates their conformation.