Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 2, 2001
Previous Article Next Article

Synthesis of 3-deazathiamine

Author affiliations

Abstract

An efficient ten-step synthesis of deazathiamine is described. The synthesis starts from commercially available α-acetyl-γ-butyrolactone and proceeds via deamination of the key aminothiophene 6. The Gewald synthesis of thiophenes is shown to give a mixture of isomeric products with the unsymmetric ketone used here and so a modified procedure giving a single isomer is developed.

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Aug 2000, accepted on 17 Oct 2000 and first published on 18 Dec 2000


Article type: Paper
DOI: 10.1039/B006962K
Citation: J. Chem. Soc., Perkin Trans. 1, 2001,0, 144-148

  •   Request permissions

    Synthesis of 3-deazathiamine

    D. Hawksley, D. A. Griffin and F. J. Leeper, J. Chem. Soc., Perkin Trans. 1, 2001, 0, 144
    DOI: 10.1039/B006962K

Search articles by author

Spotlight

Advertisements