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Issue 22, 2001
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Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones

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Abstract

The electrophilic amination of a β-aminolactam, itself derived from the conjugate addition of O,N-dibenzylhydroxylamine to a highly activated α,β-unsaturated bicyclic lactam, provides direct access to conformationally constrained diamines. Sequential deprotection allows the synthesis of 3,4-diaminopyroglutaminols.

Graphical abstract: Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones

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Publication details

The article was received on 26 Jul 2001, accepted on 19 Sep 2001 and first published on 25 Oct 2001


Article type: Paper
DOI: 10.1039/B106783B
J. Chem. Soc., Perkin Trans. 1, 2001, 3007-3012

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    Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones

    P. W. H. Chan, I. F. Cottrell and M. G. Moloney, J. Chem. Soc., Perkin Trans. 1, 2001, 3007
    DOI: 10.1039/B106783B

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