Issue 22, 2001

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones

Abstract

The electrophilic amination of a β-aminolactam, itself derived from the conjugate addition of O,N-dibenzylhydroxylamine to a highly activated α,β-unsaturated bicyclic lactam, provides direct access to conformationally constrained diamines. Sequential deprotection allows the synthesis of 3,4-diaminopyroglutaminols.

Graphical abstract: Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones

Article information

Article type
Paper
Submitted
26 Jul 2001
Accepted
19 Sep 2001
First published
25 Oct 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 3007-3012

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones

P. W. H. Chan, I. F. Cottrell and M. G. Moloney, J. Chem. Soc., Perkin Trans. 1, 2001, 3007 DOI: 10.1039/B106783B

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