Issue 19, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis of 6,7-dehydroartemisinic acid

Lai-King Sya  and  Geoffrey D. Brown*a  

* Corresponding authors

a Chemistry Department, The University of Hong Kong, Pokfulam Rd., Hong Kong
E-mail: gdbrown@hkucc.hku.hk
Fax: 852-2857 1586
Tel: 852-2859 7915

Abstract

The natural product 6,7-dehydroartemisinic acid from Artemisia annua has been synthesized in four steps from artemisitene, which was in turn prepared in four steps from commercially available artemisinin. The forward synthesis involves the acid degradation of artemisitene and some comparisons are made between the products from this reaction and the more extensively studied acid degradation reaction of its 11,13-dihydro analogue, artemisinin.

Graphical abstract: Synthesis of 6,7-dehydroartemisinic acid

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B104471K
Article type
Paper
Submitted
21 May 2001
Accepted
02 Jul 2001
First published
11 Sep 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 2421-2429

Permissions

Request permissions

Synthesis of 6,7-dehydroartemisinic acid

L. Sy and G. D. Brown, J. Chem. Soc., Perkin Trans. 1, 2001, 2421 DOI: 10.1039/B104471K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements